Rolls-Royce will cut 4,600 managerial and support jobs as the jet engine maker introduces its latest restructuring plan.
Most of the jobs to be axed will hit the UK hardest, where the FTSE 100 company employs 23,000 out of a global workforce of 50,000.
A third of the jobs are expected to go by the end of this year and the rest by the middle of 2020.
Rolls-Royce chief executive Warren East signalled the move in March as the company battled to keep to its financial targets as it struggles to get on top of problems with its Trent 1000 engines.
It has replaced the fan blades on turbines on all Boeing 787 airplanes after cracks and corrosion were found on jets operated by Japan’s ANA airline.
Mr East said: It is never an easy decision to reduce our workforce, but we must create a commercial organisation that is as world-leading as our technologies. To do this we are fundamentally changing how we work.
These changes will help us deliver over the mid and longer-term a level of free cash flow well beyond our near-term ambition of around £1bn by around 2020, he added.
The latest restructuring plan will cost the company £500m and is expected to save it as much as £400m a year by the end of 2020.
Rolls-Royce has already seen around 600 managers leave since 2015 under a previous cost-cutting programme. But this is the biggest cull since 2001, when 5,000 jobs were cut, including 1,000 contractors.
Unite assistant general secretary Steve Turner said: This announcement will be deeply unsettling for Rolls-Royce workers and their families and could have a dire economic impact on local communities reliant on Roll-Royce jobs.
There is a real danger that Rolls-Royce will cut too deep and too fast with these jobs cuts, which could ultimately damage the smooth running of the company and see vital skills and experience lost.
Over the coming days Unite will be working with Rolls-Royce, relevant agencies and other employers to find people affected alternative employment and to retain skills in the aerospace sector.
Before the latest issues, it had expected a £340m hit for this year to cover the cost of carrying out repairs on existing engines. The company is also compensating airlines for the repairs and leasing replacement aircraft.
The Federal Aviation Administration (FAA), which is the civil aviation watchdog in the United States, warned operators of the 787 to fly within 60 minutes of an airport in case of an emergency.
(c) Sky News 2018: 4,600 jobs to go at jet engine maker Rolls-Royce