One person is trapped and three others are described as “walking” after an HGV and a second vehicle collided on Blackwater Road at around 9.30am (Friday).
Isle of Wight Fire and Rescue says it was called to the A3056, between Top Line Windows and Mole Valley Country Stores.
The road is closed.
Isle of Wight ambulance says two of its crews are on scene
Southern Vectis says route 2 buses are diverting via Rookley in both directions.
**UD** The road has now reopened, say police.