From Monday (25 March), motorists will be able to travel into Newport via Staplers Road, but will they leave via Fairlee Road.
Southern Water is continuing to make repairs to pipes under the road and a one-way system has been in place for several weeks.
The system will be reversed overnight on Sunday and a temporary total road closure will be in place, to allow that to happen.
Isle of Wight Council requested the changes.
The change in direction will impact local bus services, warns Southern Water.
Staplers Road is expected to open completely on 12 April.