Firefighters are at the scene of a crash on the Downs Road this morning (Tuesday) and a person is trapped, says Isle of Wight Fire and Rescue.
Two cars are involved, near the Knighton turnoff.
Two crews from Ryde were called to the Downs Road at about 7.20am.
Southern Vectis says it has meant a delay to its 7:37, which had to take an alternative route.
Hampshire Constabulary says it was called at 7.17am to Brading Junction. It says one person was taken to hospital.
The Isle of Wight Ambulance Service has confirmed two people have been taken to hospital.