A person was cut free from a Land Rover that is on its side outside East Cowes’ town hall on Monday lunchtime.
Fire crews and police were called to York Avenue.
Photos showed the vehicle the wrong way round on the one-way system.
According to police, a car collided with a parked car on the busy main route, blocking the road.
Isle of Wight Fire and Rescue says it stabilised the vehicle and freed a person who is now in the care of the ambulance service.
The road to Red Funnel’s marshalling yard and the Floating Bridge is blocked.
**UD at 14:50
Isle of Wight Radio has been told the road has now reopened.