The Joint Operations Roads Policing Unit of Hampshire and Isle of Wight Constabulary and Thames Valley Police made more than 700 arrests as part of Operation Holly last year.
The annual Christmas Drink and Drug Driving Campaign was led by the National Police Chief’s Council (NPCC).
From December 1 to 31, officers carried out targeted patrol activity in order to stop drivers and carry out drink and drug road side testing.
A total of 286 arrests were made across Hampshire and the Isle of Wight as part of the operation.
Of those, 153 were for drink driving and 133 were for drug driving.
The campaign was backed this year by Karen Marchant, who lost her 15-year-old daughter Rebecca when she was killed by a drink driver in February 2016.
Chief Inspector Chris Spellerberg, of the Joint Operations Roads Policing Unit, said:
"While I am pleased this year's campaign has been a success with so many arrests, there are still too many people continuing to get behind the wheel despite being under the influence.
"Anyone who drives after drinking or taking drugs is putting the lives of innocent people at risk.
"All too often drink or drug driving leads to devastating collisions where people are killed or seriously injured.
"Even the smallest amount of alcohol or drugs can impair your ability to drive and we hope the message of this campaign gets through."
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