Sir Keir Starmer is set to reveal his Labour's "plan for change" as he looks to draw a line under a tough first five months in office amid public anger over budget proposals.
The prime minister will set out milestones in key policy areas to achieve the targets laid out in the manifesto.
Sir Keir has described it as the "next phase" of government that will allow the public to hold him and his team to account on their promises and will be reached by the end of the parliament.
The milestones will run alongside public sector reform, Downing Street said.
Writing in The Sun on Sunday, the prime minister compared "focusing the machinery of government" to "turning an oil tanker" and said that "acceptance of managed decline" has "seeped into parts of Whitehall".
"The British people aren't fools. They know a ruthless focus on priorities is essential," he wrote.
Labour's missions, as laid out in their July election manifesto, focus on economic growth, energy security and cleaner energy, the NHS, childcare and education systems, as well as crime and criminal justice.
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Ahead of revealing the details, Sir Keir said in a statement: "This plan for change is the most ambitious yet honest programme for government in a generation.
"Mission-led government does not mean picking milestones because they are easy or will happen anyway - it means relentlessly driving real improvements in the lives of working people.
"Some may oppose what we are doing and no doubt there will be obstacles along the way, but this government was elected on mandate of change and our plan reflects the priorities of working people."
Meanwhile, polling for The Observer newspaper by Opinium has indicated that more than half of the public disapprove of the prime minister's performance.
According to the survey of approximately 2,000 adults, 54% of people disapprove of his performance, compared with 22% who approve, leaving him with a net rating of -32%.
There will be more on this story on Sky News' Sunday Morning with Trevor Phillips, as he is joined by Chancellor of the Duchy of Lancaster Pat McFadden and shadow environment secretary Victoria Atkins from 8.30am.
(c) Sky News 2024: Sir Keir Starmer to outline his 'plan for change' focusing on schools, NHS and efficiency